With expert insights from Dr. Marielaina Perrone, DDS
The field of regenerative dentistry is rapidly evolving, offering exciting possibilities for enhanced healing, reduced invasiveness, and long-term preservation of oral structures. From platelet-rich fibrin (PRF) to stem cell therapy, these biological tools are reshaping how clinicians approach procedures such as extractions, implant placement, periodontal therapy, and bone grafting.
For dental professionals committed to minimally invasive, biologically driven outcomes, understanding and incorporating regenerative techniques can improve patient satisfaction and clinical success rates. We spoke with Dr. Marielaina Perrone, DDS, a cosmetic and implant dentist in Henderson, NV, who integrates regenerative tools into her practice.
“Regenerative dentistry allows us to partner with the body’s natural healing mechanisms,” Dr. Perrone says. “It’s a more holistic, predictable, and efficient approach to tissue regeneration and recovery.”
The Biological Foundation: Harnessing the Body’s Healing Potential
Regenerative dentistry is rooted in the concept of stimulating or accelerating the body’s healing processes to restore lost or damaged tissues. Central to this approach are biologic agents like PRF, growth factors, and even autologous stem cells, which promote cellular proliferation, vascularization, and tissue maturation.
“Instead of relying solely on synthetic grafts or pharmaceuticals, we’re using the patient’s own blood or biologic materials to create a healing-rich environment,” explains Dr. Perrone. “It reduces inflammation, enhances soft tissue closure, and improves the quality of regenerated bone.”
Platelet-Rich Fibrin (PRF): A Clinical Game Changer
PRF is one of the most widely adopted regenerative tools in dentistry today. Created by centrifuging the patient’s blood without anticoagulants, PRF contains a high concentration of platelets, leukocytes, cytokines, and a fibrin matrix that supports the sustained release of growth factors.
Clinical Applications of PRF:
- Socket preservation after extraction
- Ridge augmentation
- Sinus lift procedures
- Periodontal defect regeneration
- Peri-implant soft tissue management
- Accelerated healing post-surgery
“I use PRF routinely in surgeries involving extractions and implants,” Dr. Perrone notes. “It significantly reduces post-operative discomfort and enhances soft tissue response.”
In addition to its biological benefits, PRF is cost-effective, easy to prepare chairside, and minimally invasive, making it a practical addition to most general or surgical practices.
Stem Cell Therapy and Tissue Engineering
While still in earlier phases of clinical translation, dental stem cell research is opening new doors. Stem cells harvested from dental pulp, periodontal ligament, or adipose tissue may one day allow dentists to bioengineer entire tooth structures, regenerate alveolar bone, or reverse periodontal damage.
Although routine stem cell therapy is not yet standard in private practice, clinical trials, and lab models show promising potential for:
- Whole pulp regeneration
- Root development in immature teeth
- Periodontal ligament and alveolar bone regeneration
- Peri-implant osseointegration enhancement
“We’re only scratching the surface with stem cell applications,” says Dr. Perrone. “In the next decade, we’ll see more FDA-approved therapies that will fundamentally change how we treat tissue loss and chronic periodontal disease.”
Regenerative Strategies in Implantology
In implant dentistry, regenerative techniques ensure osseointegration and long-term success. Combining PRF membranes with bone graft materials enhances volume stability and reduces graft resorption. PRF has also been shown to support faster soft tissue closure and lower infection risk in surgical sites.
“For patients with compromised bone volume, regenerative materials allow us to preserve or rebuild what’s needed for optimal implant placement,” Dr. Perrone explains. “That means fewer complications and better long-term function.”
Collagen matrices, xenografts, and alloplastic materials are often enhanced when combined with biologics like PRF, creating a hybrid approach to hard and soft tissue healing.
Patient-Centered Benefits of Regenerative Dentistry
For modern dental practices, regenerative dentistry is more than a clinical innovation—it could be a practice differentiator. Patients are increasingly aware of and interested in biologically based treatments that minimize synthetic materials and promote natural healing.
Key Patient Benefits:
- Less postoperative discomfort
- Faster recovery time
- Reduced need for antibiotics or narcotics
- Natural, autologous materials used in treatment
- Lower long-term complication rates
“Patients love knowing we’re using their own body to heal,” Dr. Perrone adds. “It builds trust and aligns with the trend toward holistic healthcare.”
Implementation: What General Dentists Should Know
The learning curve for clinicians interested in adopting regenerative protocols is manageable. Dr. Perrone recommends starting with PRF, which requires only a centrifuge, sterile tubes, and simple blood draws—often achievable without a steep capital investment. This reassurance should give you the confidence to take the first steps towards incorporating regenerative dentistry into your practice.
“PRF is an excellent entry point,” she says. “It’s versatile, evidence-based, and the training is widely available. It’s a great way to elevate the quality of care in general and surgical procedures.”
Additional training in implantology, grafting, or advanced periodontal therapy will further support the integration of regenerative techniques into everyday workflows.
Conclusion: A Future Built on Regeneration
As dentistry evolves, integrating regenerative strategies will become increasingly standard across disciplines. Whether placing implants, managing extractions, or treating periodontal disease, regenerative tools offer a biologically sound, patient-friendly path forward. This transformative potential of regenerative dentistry is not just the future-it's already here, and it's one of the most exciting, rewarding ways to practice.
If you're interested in learning more about regenerative dentistry, I encourage you to seek out additional resources, attend relevant conferences or workshops, and consider incorporating these techniques into your practice. “Regenerative dentistry isn’t just the future — it’s already here,” says Dr. Perrone. “And it’s one of the most exciting, rewarding ways to practice.”
About the Author
Dr. Marielaina Perrone, DDS, is a nationally recognized cosmetic and implant dentist in Henderson, NV. With over 20 years of clinical experience, she offers comprehensive smile restorations utilizing regenerative techniques, implant therapy, and aesthetic dental solutions. She is a proponent of biologically driven dentistry and personalized patient care.