Burning mouth syndrome (BMS) is a chronic condition characterized by persistent burning, tingling, or numbness in the mouth—often without visible signs. Mostly affecting middle-aged women, BMS can significantly reduce quality of life. As traditional treatments offer inconsistent results, interest is growing in low-level laser therapy (LLLT)—also known as photobiomodulation—as a potential noninvasive solution.
What Does the Research Say?
A 2024 study from Hebrew University explored LLLT's effects over 10 weeks in 30 BMS patients. Researchers noted a significant drop in pain scores—from an average of 7.8 down to 2.1—immediately after treatments, with incremental benefits over time.
Meta-analyses of 14 randomized controlled trials have reported similar results: LLLT appears to reduce burning pain compared to placebo or clonazepam, while also offering modest boosts in quality of life and emotional well-being.
However, caution is warranted. Some trials found benefits only modest or short-lived, and research methods vary widely—differences in laser types, dosages, and schedules make it hard to prescribe a standard protocol. The varying results could be due to differences in patient populations, disease severity, or even the specific symptoms experienced.
Clinical Experience and Perspective
We asked Dr. Marielaina Perrone, DDS, a cosmetic dentist in Henderson, NV, to weigh in:
“Low-level laser therapy offers a promising — and non-pharmacologic — approach for BMS,” she says. “Patients often experience relief without the side effects associated with medications.”
Dr. Perrone adds:
“It’s important to frame LLLT as part of a comprehensive treatment plan, not a cure-all. Results are encouraging, but it isn't effective for every patient.”
LLLT may be especially useful for patients who cannot tolerate systemic medications or prefer conservative options.
Practical Considerations for Dentists
For dental professionals considering LLLT, these points are key:
- Device selection: Different wavelengths and power settings can affect outcomes.
- Treatment protocols: Current studies use weekly or bi-weekly sessions ranging from 4 to 10 weeks.
- Patient selection: Ideal candidates lack visible mucosal issues and prefer low-risk approaches.
- Setting expectations: Inform patients about potential need for repeat or maintenance sessions.
The Bottom Line
Although more high-quality clinical trials are needed, the current research and practitioner experience suggest that LLLT may reduce burning symptoms and enhance quality of life for BMS sufferers, with minimal risk. This potential should reassure the dental community about the future of BMS treatment.
“Low-level laser therapy is a valuable tool in our toolkit,” concludes Dr. Perrone. “It offers hope for those with persistent or unexplained oral discomfort.”
About the Author
Dr. Marielaina Perrone, DDS, is a cosmetic and implant dentist based in Henderson, NV. She is an expert in laser therapies and facial rejuvenation methods, with a particular focus on their application in oral health. Dr. Perrone is committed to blending evidence-based innovation with compassionate patient care.