Exploring DNA Methylation in Trigeminal Ganglion: Unraveling Pain Mechanisms in Orofacial Pain

Posted: December 4, 2024
The study investigated DNA methylation changes in trigeminal ganglion of rats with orofacial pain induced by experimental tooth movement. Results showed significant methylation alterations in CpG islands and shores in promoter regions, highlighting the role of DNA methylation in pain regulation. Key pathways related to endocrine, nervous, and immune systems were identified. Genes like Ctnnb1, Dlg4, and Creb1 were linked to pain through methylation variations. These findings offer valuable insights into the molecular mechanisms of orofacial pain, aiding in the development of targeted pain management strategies in dentistry.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39633318/
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