Study Uncovers Role of Sex-Dependent Salivary Bacterium in Oral Mucositis After Transplant

Posted: November 27, 2024
A groundbreaking study reveals the influence of a sex-dependent salivary bacterium, Oribacterium asaccharolyticum, on the severity of oral mucositis after allogeneic hematopoietic cell transplantation (alloHCT). The study highlights the significance of the oral microbiota in impacting oral mucositis (OM) severity, a common complication post-transplant. Notably, the presence of O. asaccharolyticum in saliva before transplantation is associated with more severe OM 14 days after alloHCT. This sex-predilection bacterium is correlated with higher uric acid levels in men, presenting a novel pathway in OM pathogenesis. The findings indicate a potential target for preventative interventions and emphasize the importance of understanding the oral microbiota in managing OM post-transplant.
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