Salivary Biomarkers CST4 and miR-223 Enhance Gastric Cancer Detection

Posted: September 23, 2025
Gastric cancer, a significant contributor to cancer-related mortality, necessitates early detection for improved outcomes. Recent research delves into using salivary biomarkers CST4 and miR-223, integrated with various health-related factors, to enhance early gastric cancer detection. A study involving 45 patients with gastric cancer and 45 healthy controls explored the diagnostic potential of these biomarkers. Saliva samples were analyzed for CST4 and miR-223 levels, alongside gathering data on factors like hot drink consumption, gastric ulcer history, Helicobacter pylori infection, BMI, DMFT, and dietary habits.

Significant differences were noted in salivary CST4 and miR-223 levels between gastric cancer patients and healthy controls. The combination of these salivary biomarkers with health-related factors exhibited high accuracy, with an AUC of 0.89, indicating promising diagnostic potential. Multiple logistic regression analyses further identified health factors like gastric ulcer history and Helicobacter pylori infection as valuable predictors of gastric cancer risk. The integration of these biomarkers and health-related parameters offers a more comprehensive approach to early gastric cancer detection, enhancing sensitivity and specificity in risk assessment.

This study underscores the potential of integrating salivary biomarkers CST4 and miR-223 with health-related factors as non-invasive tools for early gastric cancer detection. By combining these biomarkers with pertinent health data, such as gastric ulcer history and Helicobacter pylori infection, clinicians can improve risk assessment accuracy and enhance early detection strategies for gastric cancer, addressing the critical need for effective screening methods in combating this serious health concern.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40978205/

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