Apolipoprotein E4 Allele and Periodontal Antibodies Impact Cognition in Older Adults

Posted: September 10, 2025
A study examined the relationship between the Apolipoprotein E4 (APOE4) allele, antibodies against periodontal microorganisms, and cognitive function in older adults from the NHANES III study. Among 1644 participants aged 60 and older, those with APOE4 alleles showed lower cognitive scores. While specific antibody clusters were linked to cognitive scores, APOE4 alleles did not alter this association. The study suggests that APOE4 carriers had lower cognitive scores but found no modification in the link between antibodies and cognition in older adults without cognitive impairment. Further research in larger studies is needed to confirm these findings.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40919417/
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