Salivary Protectin D1 Levels Rise in Periodontitis Patients with Metabolic Syndrome Post-Therapy

Posted: September 8, 2025
A study compared periodontitis patients with and without metabolic syndrome after non-surgical periodontal therapy, finding worse baseline profiles in the metabolic syndrome group. Both groups showed improved periodontal health and increased salivary Protectin D1 levels after treatment, with no significant intergroup difference in Protectin D1 expression. Protectin D1 correlated with certain parameters but did not differentiate therapeutic response between groups. The findings suggest Protectin D1 may reflect general inflammation resolution rather than metabolic syndrome-specific pathways, highlighting its potential as a biomarker for managing periodontitis and metabolic syndrome.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40916006/
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