Maple Polyphenols Inhibit Sortase, Reduce Tooth Decay Biofilms

Posted: September 2, 2025
Maple polyphenols, including (-)-epicatechin gallate, inhibit Sortase A in Streptococcus mutans, reducing biofilm formation on tooth surfaces. In vitro studies show these compounds significantly decrease bacterial attachment, with (-)-epicatechin gallate demonstrating the strongest antibiofilm activity. The natural abundance and safety of these polyphenols suggest they could be a cost-effective strategy for preventing dental caries, particularly beneficial for children. This research highlights the potential of maple-derived compounds as a safe alternative for combating tooth decay and offers a promising option for oral care products like mouthwashes.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40772959/
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