Pinoresinol Boosts Oral Barrier Integrity in Human Buccal Cells

Posted: September 9, 2025
A study found that pinoresinol, a lignan with antioxidant properties, improves oral epithelial barrier function in human buccal cell monolayers. Pinoresinol treatment reduced permeability and increased electrical resistance, indicating enhanced barrier integrity. It also upregulated tight junction-associated molecules like occludin and claudin-3, at mRNA and protein levels. These results suggest that pinoresinol strengthens the oral epithelial barrier, potentially aiding in preventing barrier dysfunction in oral diseases.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40920795/
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