Study: Most Sugar Substitutes Linked to Faster Cognitive Decline

Posted: September 5, 2025
A recent study published in Neurology followed 12,772 adults in Brazil over eight years and found that six out of seven sugar substitutes, including aspartame, saccharin, and xylitol, were associated with a 62% faster decline in memory and thinking skills. Participants consuming the highest amounts aged 52 on average experienced a cognitive decline equivalent to 1.6 years of aging. The study raises concerns about the negative effects of certain sweeteners on brain health over time, particularly in individuals under 60 and those with diabetes. While sugar substitutes are often viewed as a healthier alternative to sugar, this research suggests a potential risk to cognitive function.
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