Oral Microbiota at Day +28 Post-HCT Tied to Chronic GVHD Risk

Posted: September 4, 2025
A study of 37 patients undergoing allogeneic hematopoietic cell transplantation found a significant association between the composition of oral microbiota at day +28 post-transplantation and the risk of chronic graft-versus-host disease (cGVHD). Streptococcus sanguinis and Prevotella loescheii in the plaque samples at day +28 were identified as linked to cGVHD. Metagenomic analysis revealed microbial metabolic pathways, such as ethanolamine utilization and glycerol metabolism, associated with future cGVHD, particularly attributed to S. sanguinis. These findings suggest a potential early prophylactic target to mitigate the risk of cGVHD in patients post-transplantation.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40905099/
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