Salivary Metabolites Linked to Chronic Craniofacial Pain in Metabolomic Study

Posted: September 4, 2025
Summary: A metabolomic analysis investigated salivary metabolites as potential biomarkers for chronic craniofacial and orofacial pain. Using UPLC-MS, 28 metabolites associated with pain conditions were examined, revealing significant differences in 18 metabolites between the pain group and controls. Seven metabolites, including DL-Isoleucine and DL-Tryptophan, consistently showed elevated levels in the pain group. These findings suggest a connection between specific salivary metabolites and pain, emphasizing the complexity of pain mechanisms. Further research is crucial to understand the implications and causality of these metabolic changes, potentially paving the way for personalized pain management strategies. The study underscores the importance of exploring salivary metabolites as biomarkers in diagnosing and managing chronic craniofacial and orofacial pain.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40906040/
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