Transcription Factor Atoh1 Stimulates Odontogenic Differentiation in Human Dental Pulp Stem Cells

Posted: January 20, 2025
The article explores the role of the transcription factor Atoh1 in promoting odontogenic differentiation in human dental pulp stem cells (DPSCs). Through ectopic expression of Atoh1 in DPSCs, researchers observed significant increases in DPSC proliferation, BMP/Wnt signaling, expression of osteogenic factors, and dentin matrix mineralization. This study unveils a novel odontogenic mechanism facilitated by Atoh1, presenting a potential gene-based strategy for regenerating the pulp-dentin complex.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39833721/
Views: 6
Sponsors
Townie Perks
Townie® Poll
Who or what do you turn to for most financial advice regarding your practice?
  
The Dentaltown Team, Farran Media Support
Phone: +1-480-445-9710
Email: support@farranmedia.com
©2025 Dentaltown, a division of Farran Media • All Rights Reserved
9633 S. 48th Street Suite 200 • Phoenix, AZ 85044 • Phone:+1-480-598-0001 • Fax:+1-480-598-3450