Circular RNA hsa_circ_0001599 Enhances Odontogenic Differentiation in Human Dental Pulp Stem Cells

Posted: January 17, 2025
The article explores how hsa_circ_0001599 promotes odontogenic differentiation of human dental pulp stem cells (hDPSCs) by enhancing ITGA2 expression and stability. It was found that overexpression of hsa_circ_0001599 activates the PI3K/AKT signaling pathway, facilitating odontogenic differentiation in hDPSCs. Mechanistically, hsa_circ_0001599 enhances ITGA2 expression by interacting with miR-889-3p and promotes ITGA2 mRNA stability through hnRNPA2B1. This research highlights the potential of hDPSCs engineered with hsa_circ_0001599 as therapeutic targets for dental pulp repair and regeneration.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39825107/
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