ATF3 Promotes M2 Macrophage Polarization to Protect Against Pulp Inflammation

Posted: January 13, 2025
The study investigates the role of ATF3 in protecting against pulp inflammation by promoting M2 macrophage polarization through WNT4 regulation. ATF3 reduces pulp necrosis, lowers pro-inflammatory factors, and enhances M2 macrophage polarization. It binds to the WNT4 promoter to positively regulate WNT4 expression, inhibiting inflammatory responses and promoting osteogenic differentiation of dental pulp stem cells. ATF3 emerges as a potential therapeutic target for treating pulpitis.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39801194/
Views: 3
Sponsors
Townie Perks
Townie® Poll
Who or what do you turn to for most financial advice regarding your practice?
  
The Dentaltown Team, Farran Media Support
Phone: +1-480-445-9710
Email: support@farranmedia.com
©2025 Dentaltown, a division of Farran Media • All Rights Reserved
9633 S. 48th Street Suite 200 • Phoenix, AZ 85044 • Phone:+1-480-598-0001 • Fax:+1-480-598-3450