Genetic Insights into Tooth Dimension Variability in Humans and Evolutionary Significance

Posted: January 6, 2025
The genetics of variation in tooth crown dimensions were explored using multiomics analyses in a cohort with mixed continental ancestry. Significant associations were found at 18 genome regions, including the EDAR gene impacting dental features. Notably, PITX2 and HS3ST3A1 were identified as candidate genes affecting tooth development, with associated SNPs overlapping enhancers active in dental cells. Knockout mice studies confirmed alterations in dental morphology. Moreover, Neanderthal introgression in HS3ST3A1 indicates its role in tooth size variation during human evolution.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39672157/
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