Alendronate Treatment Rescues Periodontal Defects in Osteogenesis Imperfecta Mouse Model

Posted: January 2, 2025
The study focused on periodontal defects in an osteogenesis imperfecta mouse model and the impact of alendronate treatment. OIM mice exhibited dental structure defects, alveolar bone loss, disrupted PDL fibers, and impaired collagen quality. Alendronate treatment partially rescued these defects by reducing bone resorption and improving collagen structure. This research highlights the importance of understanding and treating periodontal issues in OI patients.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39747677/
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