Investigating CHD3's Impact on Tooth Development and Cervical Width Regulation in Mice Study

Posted: December 20, 2024
The study explores the role of chromodomain helicase DNA-binding protein 3 (CHD3) in tooth development using Chd3 knockout mice. Results show that Chd3 plays a crucial role in defining tooth cervical width by regulating early growth in the apical papilla. It affects cell proliferation, Shh, Bmp, and Wnt signaling pathways in dental mesenchymal and HERS epithelial cells. Implications suggest CHD3's involvement in tooth morphogenesis and potential future applications in dental research.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39710094/
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