GBP5-Mediated Autophagy Enhances Bacterial Clearance in Dental Pulp Cells

Posted: December 19, 2024
The study demonstrates the role of Guanylate-binding protein 5 (GBP5) in promoting the clearance of intracellular Fusobacterium nucleatum (F. nucleatum) in dental pulp cells during pulpitis. GBP5, an IFN-inducible GTPase, activates autophagy to defend against bacterial infections. Enhancing GBP5 expression in human dental pulp cells increases bacterial clearance efficiency and activates autophagic flux. This highlights the potential of GBP5-mediated autophagy as a mechanism in combating microbial threats in dental pulpitis.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39702141/
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