Case Report: Adult Hypophosphatasia Diagnosed After Tooth Loss in Orthodontic Treatment

Posted: December 20, 2024
Adult hypophosphatasia, a rare disorder affecting mineral homeostasis, can lead to dental complications and tooth loss. This case report highlights a 38-year-old male patient diagnosed with adult hypophosphatasia after tooth loss during orthodontic treatment. Genetic analysis identified mutations in the ALPL gene. Mechanical stress from orthodontic treatment triggered symptoms, but enzyme replacement therapy showed improvement post-tooth extraction. Dental professionals should consider hypophosphatasia in differential diagnosis for unexplained dental issues, particularly in Asian populations. Collaboration between orthodontic and medical specialists is essential for timely diagnosis and management.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39702252/
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