New Insights: Glutamine-αKG Axis Impact on Dental Tissue Regeneration and Stem Cell Differentiation

Posted: December 18, 2024
The article explores the impact of the glutamine-α-ketoglutarate (αKG) axis on dentin regeneration and the regulation of osteo/odontogenic differentiation of mesenchymal adult stem cells (m-ASCs). Through metabolomic analysis and experimental models, it was found that αKG promotes dental tissue repair and dentin formation. The study highlights the significance of GLUD1 and IGF2 in this process, showing that inhibiting the glutamine-αKG axis can affect IGF2 translation efficiency. This research opens up new possibilities for dental tissue regeneration therapies and metabolite-based drug development.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39695862/
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