Study Reveals Peroxisomal Dysfunction Impairs Odontogenesis in Pex11b-Deficient Mice

Posted: December 10, 2024
The article highlights the impact of peroxisomal dysfunction on odontogenesis in Pex11b-deficient mice, leading to delayed teeth development and defects in dental cells. The study reveals reduced peroxisome number, mistargeting of catalase enzyme, and mitochondrial alterations in developing molars. Decreased staining of cytokeratin, amelogenin, and connexin 43 suggests disrupted tissue development. These findings provide valuable insights into the pathogenesis of dental pathologies in peroxisomal disorders, emphasizing the importance of peroxisomes in dental cell function and odontogenesis.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39652567/
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