Unveiling the Influence of RUNX2 Gene Variants on Dental Anomalies in Cleidocranial Dysplasia: A Revolutionary Systematic Review

Posted: December 3, 2024
A systematic review on the impact of RUNX2 gene variants in cleidocranial dysplasia (CCD) patients unveiled crucial insights. The study identified correlations between variant locations and specific dental and skeletal features in CCD. Missense variants in the functionally critical RHD region were linked to severe dental anomalies like supernumerary teeth and metopic groove. In contrast, in-frame variants in other regions exhibited milder effects. Understanding these genotype-phenotype relationships can aid in accurate diagnosis, personalized treatment strategies, and potentially guide the development of new therapies for dental anomalies in CCD.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39627759/
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