Novel Anti-Biofilm Compound from Lactobacillus rhamnosus Shows Promise Against Streptococcus mutans Biofilms

Posted: December 4, 2024
A recent study discovered a small cyclic dipeptide produced by Lactobacillus rhamnosus that exhibits promising anti-biofilm properties against Streptococcus mutans, the primary cause of dental caries. This metabolite effectively inhibits the formation of S. mutans biofilms in a dose-dependent manner, leading to a significant reduction in biofilm thickness. Through molecular analysis, the compound was identified as cyclo (-L-Leu-L-Pro) and was found to modulate gene expression crucial for biofilm formation. This research highlights a potential new approach for combating dental caries using probiotic Lactobacillus metabolites.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39624045/
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