Study Shows 1,25(OH)2D3 Enhances Osteogenic Potential in Periodontal Ligament Cells

Posted: November 29, 2024
The study explored the effect of 1,25(OH)2D3 treatment on enhancing osteogenic potential in periodontal ligament mesenchymal stem cells with low osteoblast potential. Results showed that 1,25(OH)2D3 treatment led to decreased ASPN and VDR expression while increasing BMP-2 levels, promoting RUNX2, ALP, and OCN gene expression, and enhancing mineral nodule deposition. This signifies the role of 1,25(OH)2D3 in improving osteoblast/cementoblast differentiation in periodontal ligament cells with low osteoblast potential.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39607248/
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