Study Reveals Key Mechanism Driving Odontoblastic Differentiation in Dental Pulp Stem Cells

Posted: November 27, 2024
The article explores the role of KPNB1-ATF4 inducing BNIP3-dependent mitophagy in driving odontoblastic differentiation in dental pulp stem cells (DPSCs). BNIP3-dependent mitophagy plays a crucial role in promoting DPSC differentiation into odontoblasts both in vitro and in vivo. ATF4 regulates BNIP3 expression, enhancing mitophagy, mitochondrial function, and cell differentiation potential. KPNB1 interacts with ATF4 to facilitate its translocation into the nucleus, influencing transcription and differentiation processes. This research highlights the significance of the KPNB1/ATF4/BNIP3 axis in promoting dental pulp‒dentin complex regeneration in DPSCs.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39604846/
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