Anti-Sclerostin Antibody Accelerates Orthodontic Tooth Movement in Ovariectomized Rats

Posted: November 25, 2024
The study investigated the impact of anti-sclerostin antibodies on orthodontic tooth movement in ovariectomized rats. Results showed that the group treated with romosozumab exhibited accelerated tooth movement initially, followed by a decrease later on. Micro-CT analysis revealed improved alveolar bone parameters. Osteoclasts, RANKL, OPG, and sclerostin levels decreased, while the OPG/RANKL ratio increased, indicating favorable effects on bone remodeling. This research provides valuable insights into the potential use of anti-sclerostin antibodies in enhancing orthodontic treatments and improving bone health.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39581932/
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