Irx1's Crucial Role in Oral Stem Cell Plasticity and Wound Healing

Posted: January 9, 2025
The article explores the role of Irx1 in oral epithelial basal stem cell plasticity during reepithelialization after injury. Irx1+/- mice showed delayed wound closure, morphological changes, and defective keratinocyte proliferation. IRX1 activates SOX9 for cell proliferation and EGF signaling for migration, facilitating rapid wound healing. This research highlights the significance of IRX1 in maintaining oral health and promoting efficient wound healing in the oral mucosa.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/39782692/
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